CoViD-19: Inflammation and Molecular Imaging

Europe/Rome
Remote

Remote

Franco Garibaldi (Istituto Nazionale di Fisica Nucleare)
Description


Inflammation is one of the responses of the immune system to defend and repair tissues and therefore it is a mechanism that acts to confront dangerous situations, from pathogenic microbes to traumatic events. It is not just a limited local phenomenon, as recent research has shown the existence of a significant inflammatory systemic component even in pathologies where it was considered absent or irrelevant: cardiovascular diseases, atherosclerosis and stroke, neurodegenerative diseases, tumors and infectious diseases, caused by viruses and bacteria.

Based on the evidence so far, researchers argue that CoViD-19 should be considered as an inflammatory disease, as the severity of the inflammation is often associated with a disregulation of the inflammatory immune response, that goes in overdrive. In fact, it’s becoming clear that, in particular for some of the vulnerable patient groups, it’s the response of their immune system – inflammation – that explains why they get so sick and die. Specifically, we are seeing that the risks associated with diabetes, obesity, cardiac disease, lung disease, and in general age and sex are all related to the immune system not functioning properly when confronted by the virus. Understanding inflammation is therefore very important for survival and curing from CoViD-19 while it is an extremely complex phenomenon.

Hence, the role of inflammation in CoViD-19 must be studied and understood, in particular for the strategies and techniques to be used in the battle against CoViD-19. Among the molecular imaging modalities that can play a very important and ultimately even a central role is the Nuclear Medicine imaging (PET, SPECT). Typically used so far radiological imaging techniques such as CT, MRI and ultrasound, have high sensitivity but lack specificity and mostly document the post-factum damage. By contrast, the nuclear medicine modalities allow the in-vivo detection of different physiologic and pathologic on-going phenomena and offer noninvasive tools to detect early pathophysiological changes before anatomical changes occur, and to guide treatment.

However, standard nuclear medicine techniques have limitations in terms of sensitivity and specificity (due to nonspecific standard imaging agents such as FDG). New advanced dynamic multi-organ (systemic) imaging technologies that are already available in the research arena and are constantly being improved, could translate into increased sensitivity of early detection and differentiation, in staging etc, and avoiding the long-term side effects of inflammation. In addition, novel radiopharmaceutical probes have the possibility to improve specificity of the targeted disease processes (either viral or bacterial infection, and the associated inflammation).

We believe that this is the time and we see utmost urgency to have these research advances to be transferred to the clinical research field and then to expedite its translation to clinical practice.


F. Garibaldi (co-chair) – INFN, Rome, Italy
J. Prior (co-chair) – Head of Nuclear medicine CHUV - Lausanne – Switzerland
J.M. Benlloch
i3M, University of Valencia, Spain

I. BuvatInstitute Curie, Orsay, France
V. BonviciniINFN, Trieste, Italy
G. CuttoneINFN, LNF, Catania, Italy
A. Del GuerraUniversity of Pisa, Pisa, Italy
A. GoriUniversity of Milan, Milan, Italy
M. GrigioniISS, TISP Centre, Rome, Italy
T. Jones - University of California Davis, USA
P. LecoqCERN, Switzerland
S. Majewski - University of California Davis, USA
E. Nappi INFN Bari, Italy
G .PantaleoCHUV, Division of Immunology, Lausanne, Switzerland
M. PomperJohns Hopkins University Hospital, Baltimore, MD, USA
R. RappuoliGlaxoSmithKline, Siena, Italy
M. RescignoUniversity Humanita, Milan, Italy
O. Schillaci Nuclear Medicine, University of Tor Vergata, Rome, Italy
K. Shi University Hospital Bern, Switzerland
H. Shi Fudan Hospital, Shanghai, China
A. Signore Nuclear Medicine, Sapienza University of Rome, Italy
V. SossiUniversity of British Columbia, Canada
D. Townsend - University of Singapore
H. TsoumpasUniversity of Leeds, UK
E. Vicenzi IRCCS Ospedale San Raffaele, Milan, Italy


Scientific Coordinators
Franco Garibaldi - Istituto Nazionale di Fisica Nucleare, Rome, Italy
Evaristo Cisbani - Istituto Superiore di Sanità, Rome, Italy


Local Organizing Committee
Valerio Bocci - Istituto Nazionale di Fisica Nucleare, Rome, Italy
Marco Capogni - ENEA, Casaccia, Italy
Evaristo Cisbani - Istituto Superiore di Sanità , Rome, Italy
Sandro De Cecco - Sapienza University, Rome; INFN Rome, Italy
Luca Filippi - Ospedale Santa Maria Goretti, Latina, Italy
Filippo Galli - Sapienza University of Rome, Italy
Franco Garibaldi - Istituto Nazionale di Fisica Nucleare, Rome, Italy
Mauro Grigioni - Istituto Superiore di Sanità, Rome, Italy
Alessandro Lonardo - Istituto Nazionale di Fisica Nucleare, Rome, Italy


Organizing Staff
Michela Giovagnoli - Istituto Nazionale di Fisica Nucleare, Rome, Italy
Maurizio Lucentini - Istituto Superiore di Sanità, Rome, Italy
Carmela A. Petrola - Istituto Superiore di Sanità, Rome, Italy
Alessandro Spurio - Istituto Superiore di Sanità, Rome, Italy


Technical Moderator
Fabrizio Ursini - Istituto Nazionale di Fisica Nucleare, Rome, Italy

Participants
  • Abass Alavi
  • Adriaan Lammertsma
  • Agnese Dangiò
  • Aishwarya Dhar
  • Alberto Del Guerra
  • Alberto Gola
  • Alberto Signore
  • Alessandra Bandera
  • Alessandra Palma
  • alessandra pasquo
  • Alessandra Retico
  • Alessandro Lonardo
  • Alessandro Spurio
  • Alessio Pantellini
  • Alireza Ehtesham
  • Alison Mackay
  • Andrea Garibaldi
  • Andrea Gori
  • Andrea La Fiura
  • Andreea Rasuceanu
  • Andreia Marques
  • ANDREJ LOZAR
  • Andrew Fenwick
  • Andrew Renshaw
  • angelo pagano
  • Annalisa D'Arco
  • Antonella Gazzellone
  • Antonella Rosi
  • Antonino Pietropaolo
  • Antonio Ranieri
  • Antonio Stefano Guerra
  • Arianna Carbone
  • Arthur B. McDonald
  • Arturo Chiti
  • Arzhang Cyrus Javan
  • Ashley Gillman
  • Ashley Groves
  • Aziz Ikhlef
  • Barbara Caccia
  • Bernard Bendriem
  • Betty Raman
  • Bill Worstell
  • Brahim Mehadji
  • Brian Morrison
  • Brigitta Buttari
  • Camilla Scapicchio
  • Carla Daniele
  • carla palma
  • Carlo Fiorini
  • Carmela Petrola
  • Cecilia Poli
  • Cecilia Sgadari
  • Cecilia Voena
  • Chin-Tu Chen
  • Christian Morel
  • Cinzia DaVia
  • Claudio Andenna
  • Concetta Sutera
  • Connor Bevington
  • Cristiano Galbiati
  • Cristina Ferrari
  • Cuttone Giacomo
  • Daniel Napoli`
  • Daniela Ricci
  • David Arutinov
  • David Townsend
  • Desiree Zettinig
  • Diane Brau
  • Dimitra Darambara
  • Dimitris Visvikis
  • Donatella Mandolini
  • Elham Shahinfard
  • Eliana Coccia
  • Eliluane Teixeira
  • Elisa Colaizzo
  • Elisa Vicenzi
  • Emanuele Vincenzo Pagano
  • Emiliano Mocchiutti
  • Emilie Roncali
  • Eric Guedj
  • Erika Scattone
  • Etiennette Auffray
  • Eugenio Nappi
  • Evaristo Cisbani
  • Fabiana rizzo
  • Fabiana Superti
  • Fabio Natalizia
  • Fabrizio Ursini
  • Faheem Khan
  • Farmesk Abubaker
  • Fei Gao
  • Felicia Zito
  • Filippo Fichera
  • Floriana Bartolucci
  • Francesca Brero
  • Francesca Garibaldi
  • Francesca Leek
  • Francesca Lizzi
  • francesca marzoli
  • francesca urbani
  • FRANCESCO COLLAMATI
  • Francesco Corsi
  • Francesco d'Errico
  • francesco iacoangeli
  • Francesco Laruina
  • Francesco Librizzi
  • Francesco Stellato
  • Franco Garibaldi
  • Franz Pfeiffer
  • Fulvia Arfelli
  • Gabriela Llosá
  • Gabriele Cogliati
  • Gabriele Piperno
  • Gaetano Elio Poma
  • Gaia Pupillo
  • Georgios Konstantinou
  • Germano Nobili
  • Giancarloi Rossi
  • Gianfranco De Cecco
  • Ginevra Begani Provinciali
  • giorgio parisi
  • Giovanna Failla
  • Giovanni Ferraresso
  • Giovanni Guerrieri
  • Giovanni La Penna
  • Giuliana Tromba
  • Giuseppe Andronico
  • Giuseppe D'Avenio
  • Giuseppe Esposito
  • Giuseppe Ippolito
  • Giuseppe Marano
  • Giuseppe Sava
  • Grazia Cicala
  • Guido Gebhardt
  • Guido Maria Urciuoli
  • Harry Tsoumpas
  • Heinz Pernegger
  • Hongcheng Shi
  • Hongdi Li
  • Ian Postuma
  • Ilaria Sciamanna
  • Iole Macchia
  • Irene Polycarpou
  • Irene Volpe
  • Irène Buvat
  • Isabel Frank
  • Ismini Mainta
  • Jacopo Givoletti
  • jean-brice ALLEMANDdeBRENON
  • jean-paul bouhnik
  • Jinyi Qi
  • John Aarsvold
  • John Prior
  • Jordan Hanania
  • Jose Benlloch Baviera
  • JOSEPH André
  • Joseph Purden
  • Jung-uk Shim
  • Kris Thielemans
  • Kuangyu Shi
  • Lars Eriksson
  • Laura De Nardo
  • Laura Travascio
  • Leonardo Diaferia
  • Liliana Mou
  • Lisa Rinaldi
  • Loick Verger
  • Luc Bidaut
  • Luca Brombal
  • Luca Filippi
  • Lucia Garibaldi
  • Luigi Rigon
  • LUIGI VITELLI
  • Mabel Bernardos Martin
  • Marco Capogni
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  • Maria Antonella Tabocchini
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  • Maria Luisa De Rimini
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  • Maria Rosaria Domenici
  • Maria Stella Leone
  • Marina Giuliano
  • Marta Di Fabrizio
  • Martin Pomper
  • Martina Sollini
  • Masayuki Wada
  • Massimo Ferrario
  • Matteo Bauce
  • Matteo Regolo
  • Matthias Laubenstein
  • Matthias Streun
  • Maurizio Conti
  • Maurizio Lucentini
  • maurizio molinari
  • Maurizio Morando
  • Mauro Belli
  • Mauro Citterio
  • Mauro Grigioni
  • Mauro Iodice
  • Melissa Baggieri
  • Mezbah Shaber
  • Milena Mikhail
  • Mina Dost
  • Nasim Vafai
  • Nathalie Testart
  • NICOLA PAOLI
  • nicola semprini cesari
  • Nicolaus Kratochwil
  • Omar Benhar
  • ORAZIO SCHILLACI
  • Orietta Picconi
  • Ornella Punzo
  • Paola Di Bonito
  • Paola Sestili
  • Paul Lecoq
  • Pauline Brown
  • Pedro Rato Mendes
  • Peter Križan
  • Piero Vicini
  • Pina Cannas
  • Qiyu Peng
  • Raffaele De Leo
  • Raffaella Cabini
  • Renata Longo
  • Renaud Guignard
  • Riccardo Latella
  • Richard Caon
  • Riemer Slart
  • RIno Rappuoli
  • Roberto Perrino
  • Roger Lecomte
  • Rok Pestotnik
  • Ronald Boellaard
  • Sabrina Iacuele
  • Sandro De Cecco
  • Sandro Tomassini
  • Sara Cisternino
  • Sara Pacella
  • Sergio Lo Meo
  • Sergio Suriano
  • Silvana Del Vecchio
  • Silvia Morante
  • Silvia Morante
  • Silvia Pozzi
  • silvia reich
  • Silvia Taglieri
  • Silvia Vendetti
  • Simona Gaudi
  • SIMONE BOTTICELLI
  • Stan Majewski
  • stefaan vandenberghe
  • Stefano Cannito
  • Stefano Ragazzi
  • Surja Kiran Ghorui
  • Sveva Grande
  • Terry Jones
  • Thiago Viana Miranda Lima
  • Thomas Cazaentre
  • Thomas Frach
  • Tiziana Grassi
  • Tuomas Pantsar
  • Valentina Dini
  • Valentina Dini
  • Valentina Salvati
  • Valeria Guglielmotti
  • Valeria Rosso
  • Valerio Bocci
  • Valerio Ippolito
  • Verena Rahm
  • Vesna Sossi
  • Vitaliano Chiarella
  • Viviana Fanti
  • Wayne Hawkins
  • Yang Yang
  • Yogendra Srivastava
  • Yogendra Srivastava
  • York Hämisch