Conveners
Medical applications
- Nepomuk Otte (Georgia Institute of Technology)
Time-domain diffuse optics is a powerful non-invasive, non-ionizing and label-free technique based on the use of picosecond pulsed laser light to probe highly scattering media like biological tissues down to a depth of few centimeters to obtain functional and compositional information. This technique is opening new perspectives in various fields spanning from oncology (e.g. characterization of...
Since few years, SiPMs are replacing the standard PhotoMultiplier technology thanks to the many advantages (high efficiency, single photon sensitivity, high gain with low voltage, compact and robust, low power consumption ∼ 50 µW/mm$^2$) and lower costs, with the corresponding possibility to achieve also higher segmentations in calorimetry or other applications. Also in view of experiments at...
The use of large area SiPMs represents an impressive breakthrough in time-domain diffuse optics (TD-DO) for non-invasive diagnostics and imaging. Large area detector can improve light harvesting allowing to detect the very low number of photons re-emitted from the sample at relatively late times that have probed deep in the tissue. Large area SiPMs could thus foster the measurement of deep...
Calcium is an universal second messenger which regulates a plethora of cellular processes including cell survival, gene transcription, neuro-transmission and mitochondrial functions.
Several methods have been developed for measuring calcium intracellular concentrations ([Ca$^{2+}$]) mainly based on fluorescent or bioluminescent probes. The light emission is due to the chemical reaction...
