Speaker
Greg Zaharchuk
(Stanford University)
Description
We directly compared standard and multi-delay arterial spin labeling (ASL) MRI measurements of cerebral blood flow (CBF) to simultaneous reference [15O]-water PET scans on hybrid PET/MRI in patients with Moyamoya disease. For these Moyamoya patients (N=15) with extremely long arterial transit times, multi-delay ASL outperforms standard ASL in regional correlation and reduces bias relative to PET.
We also constructed a voxel-wise, normative CBF database from healthy controls (N=15) with PET/MRI, and identified regions of hypoperfusion in frontal and parietal regions of patients. Multi-delay ASL is more specific to areas of Moyamoya hypoperfusion (more similar to the PET reference standard), whereas standard ASL overestimates these areas due to low signal.
Primary authors
Dr
Audrey Fan
(Stanford University)
Greg Zaharchuk
(Stanford University)
