Speaker
Ferdinand Schweser
(Buffalo Neuroimaging Analysis Center, University at Buffalo)
Description
Inductively coupled plasma mass spectrometry (ICP-MS) of brain tissue has confirmed that both R2* and magnetic susceptibility increase linearly with the tissue iron concentration in humans without neurological diseases. However, being related to mesoscopic magnetic field inhomogeneities, R2* depends not only on the voxel-average concentration but also on the distribution of iron in the tissue. Quantitative Magnetic Susceptibility Mapping (QSM), on the other hand, is a recent MRI technique that may be regarded as a more direct measure of the iron concentration in the tissue. The goal of the present study was to exploit the dependence of both measures on physical interactions at different length-scales to retrieve information about the tissue micro-environment in vivo.
Primary authors
Ferdinand Schweser
(Buffalo Neuroimaging Analysis Center, University at Buffalo)
Mr
Yanis Taege
(Buffalo Neuroimaging Analysis Center, University at Buffalo)
Co-authors
Prof.
Bianca Weinstock-Guttman
(Buffalo Neuroimaging Analysis Center, University at Buffalo)
Dr
Jesper Hagemeier
(Buffalo Neuroimaging Analysis Center, University at Buffalo)
Prof.
Michael Dwyer
(Buffalo Neuroimaging Analysis Center, University at Buffalo)
Dr
Niels Bergsland
(Buffalo Neuroimaging Analysis Center, University at Buffalo)
Prof.
Robert Zivadinov
(Buffalo Neuroimaging Analysis Center, University at Buffalo)
