Speaker
Joshua Daniel Kaggie
(University of Cambridge)
Description
Mapping of quantitative MRI relaxation values is promising for improving the assessment of musculoskeletal disease. Magnetic Resonance Fingerprinting (MRF) is a new method that enables fast quantitative MRI by exploiting the transient signals caused by the variation of pseudorandom sequence parameters.
This proof-of-concept work demonstrates the utility of MR Fingerprinting in the knee. Seven participants, four of which had knee osteoarthritis (Kellgren-Lawrence (KL) grade 2 or 3), were imaged approximately 80 minutes after gadolinium injection with MRF on a 3.0T MRI. The mean T1 relaxation times were shorter by 5-20% in the KL=2,3 subjects when compared to normal subjects in cartilage.
Primary author
Joshua Daniel Kaggie
(University of Cambridge)
Co-authors
Dr
Alexandra Morgan
(GlaxoSmithKline)
Prof.
Andrew McCaskie
(Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Cambridge, UK.)
Prof.
Fiona Gilbert
(Department of Radiology, University of Cambridge, Cambridge, CB2 0QQ, UK and Cambridge University Hospitals, NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, UK.)
Dr
Graves Martin
(Department of Radiology, University of Cambridge, Cambridge, CB2 0QQ, UK and Cambridge University Hospitals, NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, UK.)
Guido Buonincontri
(PI)
Dr
James MacKay
(Department of Radiology, University of Cambridge, Cambridge, CB2 0QQ, UK and Cambridge University Hospitals, NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, UK.)
Michela Tosetti
(PI)
Dr
Robert Janiczek
(GlaxoSmithKline)
Dr
Rolf Schulte
(GE Healthcare)
