Conveners
Session 1
- Giovanni Cicuta (INFN)
Prof.
Eytan Domany
(Weizmann Institute of Science)
13/12/2017, 09:20
I will first review a “systems approach” to analysis of high throughput large gene expression datasets. The basic idea, of using existing knowledge (assigning genes to biological pathways) to transform gene level information into “coarse-grained” system-level information, has been implemented in Pathifier [1] – an algorithm that infers pathway deregulation scores for each sample, on the basis...
Emiliano De Santis
(ROMA2)
13/12/2017, 10:00
The problem of protein misfolding is of the utmost biological and medical interest, since it is at the basis of a class of pathologies known as protein conformational disorders or amyloidosis. These diseases are characterised by the mis-folding of proteins that, becoming insoluble, accumulate in aggregates of fibrillar shape. It is remarkable that all the known neuro-degenerative diseases...
Francesco Stellato
(ROMA2)
13/12/2017, 10:20
The progress in high performance computing we are witnessing today offers the possibility of accurate ab initio calculations of systems in realistic physico-chemical conditions. In this talk we present a parameter-free strategy aimed at performing a first-principle computation of the low energy part of the X-ray Absorption Spectroscopy (XAS) spectrum based on density functional theory (DFT)....
Dr
Marco Zamparo
(Politecnico di Torino)
13/12/2017, 10:40
Cramér's theorem provides a large deviation principle for the empirical mean of independent and identically distributed random variables. In this talk I establish a generalization of Cramér's theorem for renewal-reward processes associated with a constrained renewal process where one of the renewals occurs at a predetermined time. With a different interpretation of the time coordinate, this...
