by
Prof.Edward N. Trifonov(University of Haifa, Israel, and Masaryk University, Brno, Czech Republic)
→
Europe/Rome
Aula 7 (Dip. di Fisica - Edificio E. Fermi)
Aula 7
Dip. di Fisica - Edificio E. Fermi
Description
Modern law codes can be traced back to Hammurabi (3,800 years back). So are modern genetic sequences. They can be traced 3,800,000,000 years back, to the very beginning of Life. Genes of today still carry certain sequences, that are there all the time since then. Reconstruction of the distant molecular past of Life reveals that the triplets GGC and GCC were the very first codons. Natural demand of thermostability had been the guiding rule all along evolution of the codon table. It also have lead to formation of closed loops, standard elements (modules) of protein structure. The very first small genes are now reconstructed, partly with help of formatted protein sequence space, which is per se an exciting object for biomolecular studies. The networks in the space allow to establish relatedness even between sequences having not a single matching residue.! That boosts discovery of distant relatives, and establishment of evolutionary connections, especially valuable for finding common molecular roots of modern organisms. The whole story is, thus, about interpolation between complex present and simple past, and further, to zero time.
