Dec 9 – 11, 2015
Dipartimento di Fisica, Univ. Bari - INFN Sezione di Bari
Europe/Rome timezone
SM&FT 2015 Computational approaches in Quantum Field Theory, Statistical Mechanics and Complex Systems

Spontaneous knotting of DNA and other biomolecules: dynamical and functional aspects.

Dec 9, 2015, 6:30 PM
Aula B

Aula B


Prof. Cristian Micheletti (SISSA)


By using both coarse-grained models and bioinformatics approaches, we shall address a few prototypical examples of the intriguing implications of entanglement and knotting on the functional, mechanical and folding properties of various types of biomolecules. In particular, we shall discuss the kinetics of spontaneous knotting of long ssDNA chains and examine the "topological friction" accompanying their translocation through nanopores equivalent to those used in nanopore sequencing techniques. The broader implications for the ejection of knotted DNA out of viral capsids will also be discussed.

Primary author

Prof. Cristian Micheletti (SISSA)

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