We are pleased to announce the second edition of the Ultra-Intense Laser Interaction Science conference “ULIS2009@Frascati” to be held at the National Laboratories of INFN in Frascati (LNF-INFN) next May 2009, from 24th to 29th. The ULIS conference series was launched by Ph. Martin, S. Jacquemot and E. Mevel with ULIS2007 in Bordeaux with the intention of offering to researchers involved in experimental, numerical or theoretical studies on Strong Field or Ultra-High Intensity science (UHI) and Inertial Fusion for Energy (IFE) an outstanding opportunity to gather and compare their expertise and then to federate these communities. The success of ULIS 2007 exceeded the most optimistic expectations. ULIS 2009 will keep the same objectives while further opening the participation to a multidisciplinary scientific community. Topics to be addressed will then include: - New Laser Sources: High Energy – High Power - Fundamental Processes at Ultra-High Intensity - Relativistic Optics in Plasmas - Advanced IFE Schemes including Fast Ignition - Laser-driven Particle Accelerators and their potential uses - Secondary Sources, Applications and Radioprotection Issues - Attosecond science “ULIS2009@Frascati” will be hosted by LNF-INFN labs, where a frontier laboratory is being set-up with the installation of the 300 TW - 20 fs FLAME laser operating in close connection with the 150 MeV Linac of the SPARC Free Electron Laser. Across the road from INFN there is the ENEA Research Centre with its infrastructures devoted to Controlled Thermonuclear Fusion, including the ABC laser laboratory.