Speaker
Chiara Favaretto
(Istituto Nazionale di Fisica Nucleare)
Summary
Innovative radioisotopes for theragnostic applications, including ⁸⁹Zr, ⁵²Mn, copper, and terbium, are being developed at the IRCCS Sacro Cuore Don Calabria Hospital. Proton irradiation of enriched solid targets on a TR-19 medical cyclotron is employed to optimize production, purification, and quality control processes. While ⁸⁹Zr is routinely produced at ≈2 GBq, other isotopes are under development with MBq-level activities. Collaborative efforts with national laboratories and universities support preclinical validation, demonstrating the feasibility of hospital-based isotope production and providing initial data to inform future large-scale production in specialized facilities.
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Authors
Chiara Favaretto
(Istituto Nazionale di Fisica Nucleare)
Chiara Favaretto
(IRCCS Sacro Cuore Don Calabria)
Co-authors
Petra Martini
(Istituto Nazionale di Fisica Nucleare)
Alessandra Boschi
(Istituto Nazionale di Fisica Nucleare)
Licia Uccelli
(University of Ferrara)
Sara Cisternino
(Istituto Nazionale di Fisica Nucleare)
Dr
Alisa Kotliarenko
(Istituto Nazionale di Fisica Nucleare)
Liliana Mou
(Istituto Nazionale di Fisica Nucleare)
Lucia De Dominicis
(Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali di Legnaro)
Gaia Pupillo
(Istituto Nazionale di Fisica Nucleare)
Juan Esposito
(Istituto Nazionale di Fisica Nucleare)
Giancarlo Gorgoni
(ospedale Sacro Cuore - don Calabria)
Emiliano Cazzola
(Sacro Cuore Hospital)
