Speaker
Dr
Kuo-Ting Chen
Summary
Human epidermal growth factor receptor 2 (HER2) is a pivotal biomarker in breast cancer and an established target for positron emission tomography (PET) imaging. Bivalent HER2 probes offer enhanced binding avidity and improved imaging contrast; however, their synthesis remains challenging. Herein, we employed 2-cyanobenzothiazole (CBT)/1,2-aminothiol click chemistry to achieve rapid, metal-free construction of a bivalent HER2-targeted probe efficiently radiolabeled with ⁶⁸Ga, demonstrating its potential for PET imaging applications.
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Authors
Yung-Chun Liu
Ching-Wen Cheng
Yu-Ru Chu
Co-authors
Ruey-Jing Huang
Feng-Yun Jimmy Huang
(Central Taiwan University of Science and Technology)
Dr
Kuo-Ting Chen
