Statistical physics of DNA replication

by Simone Pigolotti (Okinawa Institute of Science and Technology)

Wednesday 24 May 2023, 11:00 → 12:00 Europe/Rome

Aula 2 (Dipartimento di Fisica - Ed. E. Fermi)

DNA replication is arguably one of the most fundamental processes carried out by living cells. In this seminar, I will discuss how to infer the dynamics of DNA replication in bacteria. Our method combines ideas of non-equilibrium statistical physics with experiments based on deep sequencing. Our approach reveals that the DNA replication speed in bacteria displays periodic, regular variations. I will discuss possible causes of this phenomenon and outline future directions.