NONERGODIC DYNAMICS IN THE PLASMA MEMBRANE OF LIVING CELLS
by
Diego Krapf(Department of Electrical and Computer Engineering and School of Biomedical Engineering, Colorado State University)
→
Europe/Rome
Aua Rasetti (Dipartimento di Fisica - Ed. G.Marconi)
Aua Rasetti
Dipartimento di Fisica - Ed. G.Marconi
Description
Tracking individual proteins on the surface of live mammalian cells reveals complex dynamics involving anomalous diffusion and clustering into nanoscale domains. Theoretical models show that anomalous subdiffusion can be caused by different processes. Here we study the nonergodic dynamics of voltage gated ion channels in human embryonic kidney (HEK) cells and in hippocampal neurons. We perform time series and ensemble analysis of extensive single-molecule tracking. We show that in HEK cells, weak ergodicity breaking is found to be maintained by immobilization events that take place when the proteins are captured within clathrin-coated pits. However, in hippocampal neurons, ergodicity breakin
